Gastroretentive microballoons of metformin: Formulation development and characterization

Formulation and in vitro characterization of cefpodoxime proxetil gastroretentive microballoons

BACKGROUND AND THE PURPOSE OF THE STUDY The objective of the present work was to improve bioavailability of cepodoxime proxetil through gastroretentive microballoon formulation. METHODS Microballoons of cefpodoxime proxetil were formulated by solvent evaporation and diffusion method employing hydroxypropylmethyl cellulose (HPMC) and ethyl cellulose (EC) polymers and characterized for particle...

Formulation and Evaluation of Gastroretentive Floating Microballoons of Norfloxacin

Formulation and Evaluation of Gastroretentive Floating Microballoons of Anti diabetic drug

The objective of present investigation is to design a sustained release floating microballoons of Metformin HCl using two polymers of different permeability characteristics Cellulose Acetate Butyrate (MW of 16,000) and Eudragit RS 100 (MW of 150,000) using the oil-in-oil emulsion solvent evaporation method. The prepared microballoons were studied for drug release behavior in simulated gastric f...

Gastroretentive Orlistat Microspheres: Formulation, Characterization, and In Vitro Evaluation

The present study involves the preparation and evaluation of floating microspheres of orlistat for improving drug bioavailability by prolongation of gastric residence time. The microspheres were prepared by a solvent diffusion–evaporation technique using inert polymers (Eudragit RL100, cellulose acetate, and ethyl cellulose). The effect of three formulation variables (i.e., drug/polymer ratio [...

Formulation and Evaluation of In-vitro Characterization of Gastic-Mucoadhesive Microparticles/Discs Containing Metformin Hydrochloride

The present study involves preparation and evaluation of gastric-mucoadhesive microparticles with Metformin Hydrochloride as model drug for prolongation of gastric residence time. The microparticles were prepared by the emulsification solvent evaporation technique using polymers of Carbomer 934p (C) and Ethylcellulose (EC). The microparticles were prepared by emulsion solvent evaporation method...